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http://hdl.handle.net/10872/14677
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Título : | T Cell Hyperreactivity to IL-6 in Chronic Nonviremic HBV Carriers Despite Normal IL-6 Receptor or gp130 Expression |
Autor : | BAROJA, MIREN L. SIRIT, FIRELEI L. RIVERA, HENRY GARZARO, JENNY BIANCO COLMENARES, NICOLÁS E. MACHADO, IRMA V. |
Palabras clave : | chronic nonviremic OKT3 MAb T Cell Hyperreactivity hyperreactive to monocyte interleukin- 6 phytohemagglutinin PHA-stimulated T celis IL-6 receptor |
Fecha de publicación : | 1996 |
Editorial : | VIRAL IMMUNOLOGY |
Citación : | Vol. 9;No.3 pp 187-194 |
Resumen : | We previously showed that T cells from chronic nonviremic HBsAg carriers activated with immobilized OKT3 MAb are hyperreactive to monocyte accessory signals, mainly to interleukin-6 (IL-6). We have further characterized this T cell hyperreactivity using phytohemagglutinin (PHA) as the primary activating signal. PHA-stimulated T cells from nonviremic patients had a significantly higher response to addition of monocytes, monocyte supernatants, and IL-6 alone or combined with IL-1β when compared to controls. We examined if these effects could be mediated by a differential expression of IL-6 receptor (p80) or gp130 on resting or PHA-stimulated T cells. We found that PHA, IL-6, IL-1β or IL-2 induced only small changes of the dull p80 expression on T cells. In contrast, we found a significant increase of gp130 expression on PHA-activated T cells compared to unstimulated T cells, which was down-regulated by the presence of IL-6. However, no significant differences in p80 or gp130 expression were detected between patients and controls within all the culture conditions tested. Our results confirm that IL-6 is involved in the in vitro T cell hyperreactivity of nonviremic HBV carriers and indicate that this effect is not mediated by disturbances of IL-6 receptor expression. |
URI : | http://hdl.handle.net/10872/14677 |
ISSN : | 1557-8976 |
Aparece en las colecciones: | Artículos Publicados
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