SABER UCV >
1) Investigación >
Artículos Publicados >
Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10872/16986
|
Título : | Human papillomavirus detection in head and neck squamous cell carcinoma |
Autor : | Veitía, Dayahíndara Liuzzi, Juan Ávila, Maira De Guglielmo, Zoraya Prado, Yrneh Correnti, María |
Palabras clave : | HPV squamous CARCINOMA HEAD NECK |
Fecha de publicación : | 2-Nov-2017 |
Resumen : | Introduction: Human Papillomavirus (HPV) has been associated with benign and malignant lesions in different epitheliums. The relationship
between specific genotypes of high-risk HPV and some human cancers is well established. The aim of this work was to detect the HPV genotypes
present in head and neck squamous cell carcinoma (HNSCC).
Methods: We evaluated 71 samples of patients with histopathological diagnosis of HNSCC. The DNA extraction was conducted with the
QIAGEN commercial kit. HPV detection and genotyping were performed by reverse hybridisation (INNO-LiPA) following the commercial
specifications.
Results: The mean age of the patients evaluated was 60.7 ± 13.11 years. The distribution of the lesions included 25 (35.20%) cases of
squamous cell carcinoma (SCC) of the oral cavity, 23 (32.39%) of larynx, 16 (22.50%) of the oropharynx, 4 (5.63%) of paranasal sinus, and
2 (2. 80%) cases of SCC of the nostril. Of the patients, 78.9% were males, and of these 76% were tobacco users and 67.6% were alcohol
consumers. The viral DNA was detected in 67.6% of the samples. The oral cavity and the larynx were the highest HPV-positivity sites with
35.40% and 29.10% respectively. The most frequent genotype was 16 as single infection (18.70%), or in combination with another HPV
types. In the oral cavity and larynx the genotypes 16 or the combination 6 and 51 were present in 11.76% and 14.28%, respectively; and in
the oropharynx the most frequent genotype was 16 in 22.50% of the cases, and in the paranasal sinus 50% presented infection with HPV-6.
We observed that tumours with most advanced size and stage presented greater HPV positivity.
Conclusions: This study shows a high percentage of HPV positivity in SCC is mainly associated with high-risk HPV. It is important to
highlight that viral infection, especially HPV-16, could be a risk factor in HNSCC progression. |
URI : | http://hdl.handle.net/10872/16986 |
Aparece en las colecciones: | Artículos Publicados
|
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.
|