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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10872/17717

Título : Vitamin D and L-Isoleucine Promote Antimicrobial Peptide hBD-2 Production in Peripheral Blood Mononuclear Cells from Elderly Individuals
Autor : Araujo, Zaida
Castañeda-Delgado, Julio E.
Gonzalez-Curiel, Irma
Serrano, Carmen J.
Rivas Santiago, Cesar
Enciso-Moreno, Jose A.
Rivas-Santiago, Bruno
Palabras clave : Defensins
elderly
aging
vitamin D
L-isoleucine
innate immunity
Fecha de publicación : 10-Mar-2016
Citación : Araujo. Z Et All Vitamin D and L-Isoleucine Promote Antimicrobial Peptide hBD-2 Production in Peripheral Blood Mononuclear Cells from Elderly Individuals Int J Vitam Nutr Res (2017), 1–8
Resumen : Elderly individuals are susceptible to develop infectious diseases; promoting innate immunity to prevent infections is a key issue. Human β-defensin-2 (hBD-2) is an antimicrobial peptide with antimicrobial and immunomodulatory properties. L-isoleucine and vitamin D are important molecules that induce hBD-2. The Aim of this study was to determine the use L-isoleucine and Vitamin D to induce hBD-2 in cells from healthy elderly individuals and elderly individuals with recurrent infections. We explored three groups: young adults (n = 20) used as control group, elderly adults (n = 18) and elderly with recurrent infections (n = 11). PBMCs (peripheral blood mononuclear cells) were isolated from the different groups and then were treated with L-isoleucine or vitamin D3. hBD-2 concentration was assessed with a sandwich enzyme Immunosorbent assay by triplicate. Using the vehicle as a mock control. Our results showed that a percentage of the individuals responded to the treatments producing hBD-2 (p < 0.05). These results showed that both molecules induced hBD-2 in elderly individuals and can be potentially used as prophylactic therapy to decrease infection diseases rates in this vulnerable group.
URI : http://hdl.handle.net/10872/17717
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